Semax 10mg

⚙️ Mechanism of Action

Semax is thought to work via neuro-protective, nootropic, and neuro-modulatory pathways. Alzheimer’s Drug Discovery Foundation+1

Some of its known or proposed mechanisms:

Increases expression of brain-derived neurotrophic factor (BDNF) and its receptor TrkB in animal models. Alzheimer’s Drug Discovery Foundation+1
Modulates serotonin and dopamine neurotransmitter systems (in animal studies) — e.g., may potentiate stimulant-induced dopamine release. PubMed+1
Anti-inflammatory/anti-oxidative effects, and protective against hypoxic/ischemic brain injury. PMC+1
Influences gene expression in the brain in ischemic models — immune response genes, vascular genes, etc

Description

Name: Semax (chemical/peptide analog of a fragment of adrenocorticotropic hormone, ACTH) Wikipedia+2Alzheimer’s Drug Discovery Foundation+2
Structure: Heptapeptide — Met-Glu-His-Phe-Pro-Gly-Pro (often shown as MEHFPGP) PubMed+2PMC+2
Developed in Russia by the Institute of Molecular Genetics of the Russian Academy of Sciences. Wikipedia+2Alzheimer’s Drug Discovery Foundation+2
Regulatory status: Approved/used in Russia and some post-Soviet states for certain neurologic conditions; not approved by FDA in the U.S. for general clinical use.

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